9th International Conference on ICT for Sustainable Development

Authors - Janki Patel, Vaishali Thakkar, Tejas Thakkar, Saloni Dalwadi
Abstract - Bacterial vaginosis (BV) is the prevailing vaginal condition among women in the reproductive age group (14-49). The reported prevalence of BV is 50 % of total vaginal infections. Present investigation was aimed at developing the propellants and hormonal free Metronidazole (MTZ) vaginal foam formulation for the treatment of Bacterial Vaginosis using lactic acid, polysorbate 80, lecithin, and water. Mucoadhesion of the formulation was accomplished by adding different concentrations of HPMC E5 and HPMC K4M. The formulation optimization was conducted using a 23 complete factorial design, taking in-to account the cumulative percent drug released and viscosity. Drug release studies of optimized batch showed 96% release within 20 min. Formulation was also subjected to foaming tendency, foam stability, dose per actuation, antimicrobial study. An artificial neural network (ANN) was utilized as a statistical tool to enhance predictive accuracy. The results obtained from the ANN were then compared to those generated by the design expert software (DOE). To study the effectiveness, Optimized batch was subjected to antimicrobial study against varies species in comparison with commercially available metronidazole gel, Metrogyl®. Result revealed that optimized batch having greater zone of inhibition as compare to marketed formulation, because of its greater diffusivity compared to gel form.